RNA communication across kingdoms: new mechanisms and strategies in PATHogen control
Project Information

Funded by: COST action for the international cooperation of researchers, scientists, and other stakeholders

Project duration: 10/2021 − 10/2025

Website: exrnapath.eu

Contact: Dr Marjana Brkić – mbrkic@cpn.rs

Members of the network

Members of the network are scientific research organisations, universities, science centers, industry representatives and public institutions. The Center for the Promotion of Science is responsible for communication and dissemination of the results of the action.

Action coordinator: dr Amy Buck, the University of Edinburgh

Project Description

The discovery that RNA can also be found outside of cells and have a communication role led to a shift in the boundaries of research in the field of biology. Additionally, it has been shown that pathogens can use extracellular RNA (exRNA) to spread infections, and exRNAs are associated with numerous infectious diseases, both in animals and plants. However, very little is still known about the mechanisms of action of exRNA, with many open questions: how it is determined which exRNAs will be transported outside the cells, how they are transported, how they are integrated into functional pathways in the host and how pathogens use these mechanisms. In order for the potential of exRNA to be used for therapeutic and other purposes, a deep understanding of the mechanisms of action of exRNA is important. The exRNA-PATH COST action is a pioneering undertaking in Europe in the field of exRNA research, creating a network of researchers who examine the mechanisms of exRNA communication in various biological systems, with a special focus on host-pathogen interactions.

The Role of CPN

CPN contributes to the exRNA-PATH action through expertise in the field of science communication and dissemination of results and activities. The activities are aimed at:

  • determining adequate communication channels and preparing materials for the dissemination of action results, as well as identifying existing events and actions in the field of science promotion related to the potential of extracellular RNA in the field of biology and medicine,
  • science communication training for action participants.